Research explores temporary effects of low-dose atropine in young adults

University of Houston researchers have explored the temporary effects of low-dose atropine on axial length, retinal and choroidal thickness, and microvasculature.

As part of the study, which was described in Eye and Vision, 20 young adults received a single instillation of atropine – with the dose concentration ranging between 0.01%–0.1%.

They found that a single instillation does not change axial length, retinal thickness or choroidal thickness over a 24-hour period. However, the researchers did observe a transient effect on retinal perfusion.

The researchers concluded that the short-term effects of atropine on axial length and retinal and choroidal parameters may differ from long-term effects.

University of Houston Professor of Optometry, Lisa Ostrin, highlighted that the study supports a more precise, evidence-based, and individualised approach to myopia management.

“Characterising these short-term effects is important for a better understanding of the physiological responses to atropine in clinical and research settings,” Ostrin said.