09 November 2026
A new study published in Cell Biomaterials has outlined fresh insight on how tiny bumps inside the cornea contribute to cell death in Fuchs’ endothelial corneal dystrophy (FECD).
University of Waterloo researchers explained that FECD is characterised by the loss of human corneal endothelial cells as well as the formation of abnormal extracellular matrix deposits called guttata.
The scientists highlighted that the role of these tiny bumps in driving cell loss has previously remained elusive.
In the present study, researchers used a laboratory model to recreate guttata in diseases corneas. They found that the guttata contributed to cell death by placing physical stress on the corneal endothelial cells.
“This study paves the way for a better understanding of how guttata impact FECD pathophysiology and offers potential implications for future therapeutic strategies,” the authors highlighted.
FECD is one of the leading causes of corneal blindness. Many countries around the world are facing shortages of donor corneas.
Dr Evelyn Yim, a chemical engineering professor at the University of Waterloo, highlighted: “Our ultimate goal is the development of alternative treatments, which could mean fewer people will need transplants for corneal blindness due to Fuchs’ endothelial corneal dystrophy in the future.”
Identifying and monitoring Fuchs’ dystrophy in practice
A roundtable discussion on screening, managing and educating patients on Fuchs’ dystrophy in community optometry
Comments (0)
You must be logged in to join the discussion. Log in