Unravelling the mystery of why some patients with high IOP avoid glaucoma

Increased antioxidant capacity may explain how some patients with ocular hypertension are shielded from glaucomatous neurodegeneration

veg and fruit
Pixabay/Deborah Breen Whiting
A new study published in Journal of Clinical Medicine has explored why some patients have ocular hypertension but do not experience the degeneration associated with glaucoma.

Researchers from LSU Health New Orleans Neuroscience Center of Excellence and the University of Copenhagen found that patients with ocular hypertension but no glaucoma have increased antioxidant capacity and higher levels of anti-inflammatory, omega-3 derived chemical messengers.

The authors highlight: "The study opens avenues of therapeutic exploration, highlighting the significance of the omega-3 fatty acid chemical messengers' antioxidant capacity as a potential diagnostic biomarker and as a novel treatment to prevent glaucomatous neurodegeneration."

The researchers note that the study provides new insight into possible mechanisms of protection against oxidative stress in patients with ocular hypertension and may explain “the apparent tolerability” to increased intraocular pressure in these patients.