Search

CET and skills guides

Study and gain CET points through OT’s online CET exams, and access archived CET, CPD articles and skills guides in our education library

Find out more

Science and vision

News and features about the latest scientific developments and advances in optometry, ophthalmology and eye medicine

Find out more

Industry

News and features about the latest developments in optics with a focus on industry

Find out more

Professional support

News and features about the latest developments relating to professional support from across optics. This includes updates from optical organisations such as the AOP and the GOC

Find out more

In practice

News and in-depth features about business management and career development in optics

Find out more

Jobs

Explore the latest UK and global jobs in the optical sector for optometrists, dispensing opticians and more

Find out more

Timing key when administering gene therapy

A new study has highlighted that dogs receiving gene therapy before significant photoreceptor loss have less disease progression

Labrador
New research has highlighted that dogs that receive gene therapy when at least 63% of their photoreceptor cells are present had more successful outcomes than those treated at a later stage.

The study, which was published in Molecular Therapy, could provide insight for the treatment of Leber congenital amaurosis in humans. 

Researchers administered gene therapy approved by the US Food and Drug Administration to dogs with the inherited eye condition.

When dogs received the treatment with at least 63% of their photoreceptor cells present but non-functional, the effect of the treatment was lifelong in halting progressive degeneration.

However, when the dogs had lost more than half of their photoreceptor cells the disease at the time of treatment, degeneration continued despite a short-term restoration of sight.

The researchers highlight that their findings emphasise the importance of investigating therapies that prevent cell death and aim to correct the underlying genetic mutation.

Image credit: Pixabay/Chiemsee2016

Advertisement