Scientists discover stem cells in the optic nerve for the first time
The identification of neural progenitor cells in the region of the eye that transmits signals from the eye to the brain could prompt new treatments
The study, which is described in Proceedings of the National Academy of Sciences, provides new insight into how glaucoma may develop.
To carry out the research, scientists examined the optic nerve lamina, a 1mm wide band of tissue between the retina and the optic nerve.
The presence of neural progenitor cells was identified using antibodies and genetically modified animals.
After 52 trials, the neural progenitor cells were successfully grown in culture.
Study leader, Steven Bernstein, highlighted that the cells are believed to be present in the optic nerve from birth and help to nourish the nerve fibres that form the optic nerve.
"Without these cells, the fibres may lose their resistance to stress, and begin to deteriorate, causing damage to the optic nerve, which may ultimately lead to glaucoma," he said.
The research team plans on conducting studies in genetically modified mice to investigate how the depletion of lamina progenitor cells contributes to diseases such as glaucoma and prevents repair.