University of Southampton researchers develop mouse model of dry AMD

The mice could help scientists to understand disease progression and test potential new treatments


UK researchers have replicated features of dry age-related macular degeneration (AMD) in mice.

Scientists describe how the mice displayed characteristics of early stage geographic atrophy in Scientific Reports.

The researchers highlight that a lack of dry AMD models has previously been one of the factors inhibiting the development of potential new therapies targeting the condition.

Dr Arjuna Ratnayaka, from the University of Southampton, said that the research was the result of multi-disciplinary work between scientists and clinicians over a seven-year period.

“These mice could help us understand how AMD causes damage to the retina, which is desperately needed,” he said.

“This is important, as it appears that prolonged injections of Vascular Endothelial Growth Factor inhibitors, which is used to manage wet AMD in patients, can sometimes result in a switch to the dry form,” Dr Ratnayaka highlighted.

Image credit: Pixabay

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